Barbara Graziosi is a specialist in ancient Greek literature. She has published extensively on Homer and his reception, and has helped develop optical character and handwritten text recognition for ancient Greek and early modern printed Latin texts as part of the research project Living Poets: A New Approach to Ancient Poetry funded by the European Research Council for which she acted as PI. The programme for OCR has led to a 'Proof of Concept' grant, also awarded by the European Research Council, which funds further development of OCR for early modern books printed in Latin, which will in due course enable libraries to turn early books into fully searchable digital texts. Further information can be found on the projects's website and at Rescribe.

She teaches classes on Homer, Greek lyric, classical mythology, and, with Anthony Grafton, on the reception of classical antiquity in early modern Europe.